Product Overview
1, 3, 5-Trihydroxy-4-prenylxanthone | T4700 | TargetMol Chemicals
CAS: 53377-61-0
Smiles:
Formula: C18H16O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: 1, 3, 5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. 1, 3, 5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction.
Molecular Weight: 312, 3
