Product Overview
1-Aminocyclopropane-1-carboxylic acid | T4752 | TargetMol Chemicals
CAS: 22059-21-8
Smiles: NC1(CC1)C(O)=O
Formula: C4H7NO2
Pathway: Metabolism|||Neuroscience
Target: Endogenous Metabolite|||NMDAR
Receptor: N/A
Bioactivity: 1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.
Molecular Weight: 101, 105
