Product Overview
1-Hydroxy-2, 3, 5-trimethoxyxanthone | TN2534 | TargetMol Chemicals
CAS: 22804-49-5
Smiles: COc1cc2oc3c(OC)cccc3c(=O)c2c(O)c1OC
Formula: C16H14O6
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Membrane transporter/Ion channel|||Metabolism|||Neuroscience|||NF-Κb
Target: IκB/IKK|||Calcium Channel|||NOS|||5-HT Receptor|||COX
Receptor: N/A
Bioactivity: 1-Hydroxy-2, 3, 5-trimethoxyxanthone (HM-1) has vasodilator action, which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1, at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells; it also can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-Ⅱ protein expression.
Molecular Weight: 302, 3
