Product Overview
1-Naphthohydroxamic acid | T13996 | TargetMol Chemicals
CAS: 6953-61-3
Smiles: ONC(=O)c1cccc2ccccc12
Formula: C11H9NO2
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: HDAC
Receptor: N/A
Bioactivity: 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2], But it can induce tubulin acetylation.
Molecular Weight: 187, 198
