Product Overview
15-Methoxypinusolidic acid | TN2641 | TargetMol Chemicals
CAS: 769928-72-5
Smiles: COC1OC(=O)C(CC[C@H]2C(=C)CC[C@@H]3[C@]2(C)CCC[C@]3(C)C(O)=O)=C1
Formula: C21H30O5
Pathway: DNA Damage/DNA Repair|||Immunology/Inflammation|||MAPK|||Membrane transporter/Ion channel|||Metabolism|||Neuroscience|||NF-Κb
Target: ERK|||IL Receptor|||p38 MAPK|||Calcium Channel|||NOS|||NF-κB|||COX|||JNK|||NMDAR|||PPAR
Receptor: N/A
Bioactivity: 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression.
Molecular Weight: 362, 5
