Product Overview
2, 5-Dihydroxyacetophenone | TCS2170 | TargetMol Chemicals
CAS: 490-78-8
Smiles: CC(=O)c1cc(O)ccc1O
Formula: C8H8O3
Pathway: MAPK|||NF-Κb|||Proteases/Proteasome
Target: ERK|||NF-κB|||Tyrosinase
Receptor: N/A
Bioactivity: 1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2, 5-Dihydroxyacetophenone has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2, 5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models.
Molecular Weight: 152, 149
