Product Overview
2'-Fluoro-2'-Deoxyadenosine | T9727 | TargetMol Chemicals
CAS: 64183-27-3
Smiles: Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F
Formula: C10H12FN5O3
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: Nucleoside Antimetabolite/Analog
Receptor: N/A
Bioactivity: 2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.
Molecular Weight: 269, 236
