Product Overview
20-HETE | T14021 | TargetMol Chemicals
CAS: 79551-86-3
Smiles: OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Formula: C20H32O3
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: 20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, and it also inhibits endothelial NO synthase and inhibits apoptosis of pulmonary artery smooth muscle cells[1][2]. 20-HETE constricts smooth muscles, stimulates smooth muscle proliferation and migration.
Molecular Weight: 320, 473
