3-Hydroxybakuchiol | TN2945

3-Hydroxybakuchiol | TN2945 | TargetMol Chemicals

CAS: 178765-54-3

Smiles: CC(C)=CCC[C@@](C)(C=C)\C=C\c1ccc(O)c(O)c1

Formula: C18H24O2

Pathway: Apoptosis|||Membrane transporter/Ion channel|||Proteases/Proteasome

Target: ATPase|||Caspase

Receptor: N/A

Bioactivity: 3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation.3-Hydroxybakuchiol has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.

Molecular Weight: 272, 4