Product Overview
3PO | T22223 | TargetMol Chemicals
CAS: 18550-98-6
Smiles: O=C(/C=C/c1cnccc1)c1ccncc1
Formula: C13H10N2O
Pathway: Autophagy|||Metabolism
Target: Glucokinase|||Autophagy
Receptor: N/A
Bioactivity: 3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2, 6-BP, lactate, ATP, NAD+, and NADH.
Molecular Weight: 210, 23
