5, 7, 3', 4'-Tetrahydroxy-3-methoxy-8, 5'-diprenylflavone | TN3084

5, 7, 3', 4'-Tetrahydroxy-3-methoxy-8, 5'-diprenylflavone | TN3084 | TargetMol Chemicals

CAS: 1353676-65-9

Smiles: COc1c(oc2c(CC=C(C)C)c(O)cc(O)c2c1=O)-c1cc(O)c(O)c(CC=C(C)C)c1

Formula: C26H28O7

Pathway: Others

Target: Others

Receptor: N/A

Bioactivity: 5, 7, 3', 4'-Tetrahydroxy-3-methoxy-8, 5'-diprenylflavone has anti-cancer activity, it shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro, with the IC50 value of 4.41 uM. 5, 7, 3', 4'-Tetrahydroxy-3-methoxy-8, 5'-diprenylflavone can strongly down-regulate expression concentrations of estrogen receptor-α (ER-α) and is able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.

Molecular Weight: 452, 5