Product Overview
6-Acetonyldihydrochelerythrine | TN3152 | TargetMol Chemicals
CAS: 22864-92-2
Smiles: COc1ccc2-c3ccc4cc5OCOc5cc4c3N(C)[C@@H](CC(C)=O)c2c1OC
Formula: C24H23NO5
Pathway: Apoptosis|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||MAPK|||Metabolism|||Microbiology/Virology|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome
Target: ERK|||BCL|||Akt|||HIV Protease|||PPAR|||p53
Receptor: N/A
Bioactivity: 6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 cell lines, it displays potent cytotoxic activity in human HCT116 and SW620 colon carcinoma cells, to a higher extent than 5-fluorouracil (5-FU), the cornerstone chemotherapeutic agent in colon cancer.
Molecular Weight: 405, 5
