Product Overview
7α, 25-Dihydroxycholesterol | T14063 | TargetMol Chemicals
CAS: 64907-22-8
Smiles: [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O
Formula: C27H46O3
Pathway: GPCR/G Protein|||Metabolism
Target: EBI2/GPR183|||Endogenous Metabolite
Receptor: N/A
Bioactivity: 7α, 25-dihydroxycholesterol (7α, 25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
Molecular Weight: 418, 662
