Product Overview
7-Hydroxymethotrexate | T20339 | TargetMol Chemicals
CAS: 5939-37-7
Smiles: CN(Cc1nc2c(N)nc(N)[nH]c2nc1=O)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Formula: C20H22N8O6
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: 7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. 2 Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models.
Molecular Weight: 470, 446
