Product Overview
A-674563 HCl (552325-73-2(free base)) | T4444 | TargetMol Chemicals
CAS: 0
Smiles:
Formula: N/A
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||MAPK|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: ERK|||Akt|||PKA|||CDK|||PKC
Receptor: N/A
Bioactivity: A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].
Molecular Weight: N/A
