Product Overview
A 80b | T26452 | TargetMol Chemicals
CAS: 135561-94-3
Smiles: CN\N=c1\[nH]nc(-n2nc(C)cc2C)c2[nH]c3ccccc3c12
Formula: C16H17N7
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: A-80b is a synthesized pyridazino[4, 5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. Hypotensive and antihypertensive effect of A-80b possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.
Molecular Weight: 307, 361