Product Overview
A 83586C | T26456 | TargetMol Chemicals
CAS: 116364-81-9
Smiles: CC[C@@](O)(C(=O)N[C@H]1[C@@H](OC(=O)[C@H](NC(=O)[C@@H]2CCCNN2C(=O)[C@@H](C)N(C)C(=O)[C@H](C)N(O)C(=O)[C@H]2CCCNN2C1=O)[C@H](C)O)C(C)C)[C@@]1(O)CC[C@H](C)[C@H](O1)C(\C)=C\[C@H](C)C(=O)C(\C)=C\C
Formula: C47H76N8O14
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating osteopontin (Opn) expression. A-83586C also inhibits E2F-mediated transcription by downregulating E2F1 expression and inducing dephosphorylation of the oncogenic hyperphosphorylated retinoblastoma protein (pRb).
Molecular Weight: 977, 167