Product Overview
A 839977 | T14076 | TargetMol Chemicals
CAS: 870061-27-1
Smiles: Clc1cccc(c1Cl)-n1nnnc1NCc1ccccc1Oc1ccccn1
Formula: C19H14Cl2N6O
Pathway: Neuroscience
Target: P2 Receptor
Receptor: N/A
Bioactivity: A 839977 is a P2X7 selective antagonist and the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta[1]. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models.
Molecular Weight: 413, 26
