Product Overview
AC-264613 | T4186 | TargetMol Chemicals
CAS: 1051487-82-1
Smiles: CC(=NNC(=O)[C@@H]1[C@H](CNC1=O)c1ccccc1)c1cccc(Br)c1
Formula: C19H18BrN3O2
Pathway: GPCR/G Protein
Target: Protease-activated Receptor
Receptor: N/A
Bioactivity: AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
Molecular Weight: 400, 276
