Product Overview
AES-350 | T9041 | TargetMol Chemicals
CAS: 847249-57-4
Smiles: CC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1
Formula: C18H20N2O3
Pathway: Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: Apoptosis|||HDAC
Receptor: N/A
Bioactivity: AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
Molecular Weight: 312, 36
