Product Overview
Afatinib | T21312 | TargetMol Chemicals
CAS: 850140-72-6
Smiles: CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1
Formula: C24H25ClFN5O3
Pathway: Angiogenesis|||Autophagy|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Target: EGFR|||Autophagy
Receptor: N/A
Bioactivity: Afatinib is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively).
Molecular Weight: 485, 94
