Product Overview
Aflatrem | TN3351 | TargetMol Chemicals
CAS: 70553-75-2
Smiles: CC(C)(C=C)c1cccc2[nH]c3c(C[C@@H]4CC[C@]5(O)C6=CC(=O)[C@@H]7O[C@@]6(CC[C@]5(C)[C@@]34C)OC7(C)C)c12
Formula: C32H39NO4
Pathway: Membrane transporter/Ion channel|||Neuroscience
Target: GABA Receptor
Receptor: N/A
Bioactivity: Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced chloride current, the potentiating action of aflatrem on the GABAA receptor channel may explain the initial symptoms of intoxication caused by aflatrem in vivo.
Molecular Weight: 501, 66
