Product Overview
Aftin-4 | T4364 | TargetMol Chemicals
CAS: 866893-90-5
Smiles: CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
Formula: C20H28N6O
Pathway: Neuroscience|||Proteases/Proteasome|||Stem Cells
Target: Beta Amyloid|||Gamma-secretase
Receptor: N/A
Bioactivity: Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
Molecular Weight: 368, 485
