Product Overview
AG126 | T4092 | TargetMol Chemicals
CAS: 118409-62-4
Smiles: Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O
Formula: C10H5N3O3
Pathway: Immunology/Inflammation|||MAPK|||Neuroscience
Target: ERK|||COX
Receptor: N/A
Bioactivity: The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM).
Molecular Weight: 215, 168
