Product Overview
Agrimonolide | TN3364 | TargetMol Chemicals
CAS: 21499-24-1
Smiles: COc1ccc(CC[C@H]2Cc3cc(O)cc(O)c3C(=O)O2)cc1
Formula: C18H18O5
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||GPCR/G Protein|||Immunology/Inflammation|||JAK/STAT signaling|||MAPK|||Neuroscience|||NF-Κb|||Stem Cells
Target: IL Receptor|||p38 MAPK|||TNF|||NOS|||NF-κB|||COX|||JAK|||Adrenergic Receptor|||JNK|||STAT
Receptor: N/A
Bioactivity: Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. Agrimonolide and desmethylagrimonolide can effectively increase insulin-mediated glycogen level in heptocytes, they may play an important role in regulating glucose metabolism in insulin-resistance HepG2 cells and could be developed as a promising natural material for diabetes prevention and treatment.
Molecular Weight: 314, 3
