Product Overview
AKB-6899 | T29797 | TargetMol Chemicals
CAS: 1007377-55-0
Smiles: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1
Formula: C14H11FN2O4
Pathway: Angiogenesis|||Chromatin/Epigenetic|||Metabolism|||Tyrosine Kinase/Adaptors
Target: VEGFR|||HIF/HIF Prolyl-Hydroxylase|||HIF
Receptor: N/A
Bioactivity: AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.
Molecular Weight: 290, 25
