Product Overview
AKI603 | T001-00000005 | TargetMol Chemicals
CAS: 1432515-73-5
Smiles: CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(cc2)[N+]([O-])=O)n1
Formula: C19H23N9O2
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic
Target: Aurora Kinase
Receptor: N/A
Bioactivity: AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells[1][2].
Molecular Weight: 409, 454
