Product Overview
ALK-IN-1 | T3059 | TargetMol Chemicals
CAS: 1197958-12-5
Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N(C)C
Formula: C26H34ClN6O2P
Pathway: Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Target: EGFR|||IGF-1R|||ALK
Receptor: N/A
Bioactivity: AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
Molecular Weight: 529, 02
