Product Overview
Alofanib | T5122 | TargetMol Chemicals
CAS: 1612888-66-0
Smiles: Cc1cc(c(NS(=O)(=O)c2cccc(c2)C(O)=O)cc1-c1cccnc1)[N+]([O-])=O
Formula: C19H15N3O6S
Pathway: Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||FGFR
Receptor: N/A
Bioactivity: Alofanib is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
Molecular Weight: 413, 4