Product Overview
AM-2394 | T3312 | TargetMol Chemicals
CAS: 1442684-77-6
Smiles: CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1
Formula: C22H25N5O4
Pathway: Metabolism
Target: Glucokinase
Receptor: N/A
Bioactivity: AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
Molecular Weight: 423, 473
