Product Overview
AMD 3465 | T14208 | TargetMol Chemicals
CAS: 185991-24-6
Smiles: C(NCc1ccccn1)c1ccc(CN2CCCNCCNCCCNCC2)cc1
Formula: C24H38N6
Pathway: Microbiology/Virology|||Proteases/Proteasome
Target: HIV Protease
Receptor: N/A
Bioactivity: AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.
Molecular Weight: 410, 61
