Product Overview
Amiloride hydrochloride dihydrate | T0175L | TargetMol Chemicals
CAS: 17440-83-4
Smiles: O.O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Formula: C6H13Cl2N7O3
Pathway: Apoptosis|||Membrane transporter/Ion channel
Target: Apoptosis|||Sodium Channel|||TRP/TRPV Channel
Receptor: N/A
Bioactivity: Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss.
Molecular Weight: 302, 12
