Product Overview
Amsilarotene | T21314 | TargetMol Chemicals
CAS: 125973-56-0
Smiles: C[Si](C)(C)c1cc(cc(c1)[Si](C)(C)C)C(=O)Nc1ccc(cc1)C(O)=O
Formula: C20H27NO3Si2
Pathway: Cell Cycle/Checkpoint
Target: CDK
Receptor: N/A
Bioactivity: Amsilarotene inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.
Molecular Weight: 385, 61