Anti-CXCR4 Antibody

Product Name:

Anti-CXCR4 Antibody

Size:

100μg/vial

Form:

Lyophilized

Description:

Bio Anti-CXCR4 Antibody catalog # PA1237. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling:

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product:

Anti-CXCR4 Antibody (Biological Technology, Pleasanton CA, USA, Catalog # PA1237)

Host:

Rabbit

Contents:

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality:

Polyclonal

Immunogen:

A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4 (18-33aa SGDYDSMKEPCFREEN), different from the related rat and mouse sequences by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity:

No cross reactivity with other proteins

Reactive Species:

PA1237 is reactive to CXCR4 in Human, Mouse, Rat

Applications:

PA1237 is guaranteed for IHC, WB 

Background Of CXCR4:

CXCR4 (Chemokine,CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. It is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is also a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1. It functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. It was concluded that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization.

Antibody Validation:

All antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.