Anti Di Tyrosine (DT) Monoclonal Antibody

Tyrosine is one of the major targets of protein oxidation, and until today various tyrosine derivatives such as nitrotyrosine, dityrosine and halogenated tyrosine depending on the type of free radicals. DT is a tyrosine dimer derived from tyrosyl radicals which is formed by reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. DT have been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is one of the specific biomarkers for protein oxidation.

Antigen:

3-(p-hydroxyphenyl) propionic acid dimer-conjugated keyhole limpet hemocyanin.

Form:

Lyophilized power. Reconstitute by 200 µL of distilled water. 100 µg/mL of IgG.

Subclass:

Mouse IgG2a(kappa), clone 1C3. Protein A purified.

Product Type:

Monoclonal Antibody

Clone: ​​

1C3

Isotype:

Mouse IgG2akappa

Immunogen:

3-(p-hydroxyphenyl)propionic acid dimer-conjugated keyhole limpet hemocyanin.

Applications:

ELISA, IHC, WB

Species Cross-reactivity:

All, Human

Specificity:

Specific for free dityrosine, 3-(p-hydroxyphenyl) propionic acid dimer, dityrosine-BSA conjugate, and dityrosine in protein or peptides. Cross reactivity have been tested for following analogues: Nitrotyrosine, chlorotyrosine, aminotyrosine, phosphotyrosine, tyrosine, 3-(p-hydroxyphenyl) propionic acid, phenylalanine, 3,4-dihydroxyphenylacetic acid (DOPA)

Application:

Immunohistochemistry, western blotting and ELISA

Storage:

Less than -20°C