Product Overview
Apcin | T8561 | TargetMol Chemicals
CAS: 300815-04-7
Smiles: Cc1ncc(n1CCOC(=O)NC(Nc1ncccn1)C(Cl)(Cl)Cl)[N+]([O-])=O
Formula: C13H14Cl3N7O4
Pathway: Cell Cycle/Checkpoint
Target: APC
Receptor: N/A
Bioactivity: Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.
Molecular Weight: 438, 65
