Product Overview
APG-1387 | T30095 | TargetMol Chemicals
CAS: 1570231-89-8
Smiles: CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)S(=O)(=O)c1cccc(c1)S(=O)(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1
Formula: C60H72N10O10S2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's CDDP and 5-FU enhance chemoresensitivity and promote cell apoptosis in vitro and in vivo.
Molecular Weight: 1157, 42
