API-1 | T8969

API-1 | T8969 | TargetMol Chemicals

CAS: 36707-00-3

Smiles: C1=C(C(=O)C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C(=O)N

Formula: C13H15N5O6

Pathway: Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling

Target: Akt

Receptor: N/A

Bioactivity: API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .

Molecular Weight: 337, 29