Product Overview
Apomine | T26644 | TargetMol Chemicals
CAS: 126411-13-0
Smiles: CC(C)OP(=O)(OC(C)C)C(Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)P(=O)(OC(C)C)OC(C)C
Formula: C28H52O7P2
Pathway: Metabolism
Target: HMG-CoA Reductase
Receptor: N/A
Bioactivity: Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity. Apomine enhances the antitumor effect of lovastatin on myeloma cells by downregulating 3-hydroxy-3-methylglutaryl-CoA reductase.
Molecular Weight: 562, 665