Product Overview
ASP2453 | T39738 | TargetMol Chemicals
CAS: 2241719-73-1
Smiles: Cc(ccc1c2cn[nH]1)c2-c(c(C1CC1)cc(c1n2)c(N3CCC(C4)(CN4C(C=C)=O)CC3)nc2OC2CCN(CCCOC)CC2)c1OCC(F)(F)F
Formula: C40H48F3N7O4
Pathway: GPCR/G Protein|||MAPK
Target: Ras
Receptor: N/A
Bioactivity: ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.
Molecular Weight: 747, 85