Product Overview
Atabecestat | T14338 | TargetMol Chemicals
CAS: 1200493-78-2
Smiles: C[C@]1(C=CSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Formula: C18H14FN5OS
Pathway: Neuroscience
Target: BACE
Receptor: N/A
Bioactivity: Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
Molecular Weight: 367, 4