Product Overview
Avagacestat | T6249 | TargetMol Chemicals
CAS: 1146699-66-2
Smiles: NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1
Formula: C20H17ClF4N4O4S
Pathway: Neuroscience|||Proteases/Proteasome|||Stem Cells
Target: Gamma-secretase
Receptor: N/A
Bioactivity: Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Molecular Weight: 520, 88
