Product Overview
Avasimibe | T2753 | TargetMol Chemicals
CAS: 166518-60-1
Smiles: CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C
Formula: C29H43NO4S
Pathway: Metabolism
Target: P450|||Acyltransferase
Receptor: N/A
Bioactivity: Avasimibe is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9/1A2/2C19 (IC50: 2.9/13.9/26.5 μM).
Molecular Weight: 501, 73