Product Overview
AZD1283 | T3536 | TargetMol Chemicals
CAS: 919351-41-0
Smiles: CCOC(=O)c1cc(C#N)c(nc1C)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1
Formula: C23H26N4O5S
Pathway: Neuroscience
Target: P2 Receptor
Receptor: N/A
Bioactivity: AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses induced the increase in bleeding time at 33 and 100 μg/kg/min for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds.
Molecular Weight: 470, 54
