Product Overview
Barlerin | T5S1632 | TargetMol Chemicals
CAS: 57420-46-9
Smiles: COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]2[C@@H]1[C@H](O)C[C@]2(C)OC(C)=O
Formula: C19H28O12
Pathway: Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||NF-Κb|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome|||Tyrosine Kinase/Adaptors
Target: VEGFR|||TNF|||NF-κB|||Akt|||Caspase
Receptor: N/A
Bioactivity: 8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.
Molecular Weight: 448, 421