BDA366 | T3706

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€177.00 - €1,283.00
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TMC-T3706
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Product Overview

BDA366 | T3706 | TargetMol Chemicals

CAS: 1821496-27-8

Smiles: CCN(CC)C[C@@H](O)CNc1ccc(NC[C@H]2CO2)c2C(=O)c3ccccc3C(=O)c12

Formula: C24H29N3O4

Pathway: Apoptosis

Target: BCL

Receptor: N/A

Bioactivity: BDA-366 specifically targets the BH4 domain of Bcl2 BDA-366 and suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without obvious effects on normal hematopoietic cells or body weight.

Molecular Weight: 423, 513

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