Product Overview
Belinostat | T1852 | TargetMol Chemicals
CAS: 414864-00-9
Smiles: ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Formula: C15H14N2O4S
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: HDAC
Receptor: N/A
Bioactivity: Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
Molecular Weight: 318, 35
