Product Overview
BI-0115 | T9108 | TargetMol Chemicals
CAS: 4929-23-1
Smiles: O=C1N(CCC)C2=CC=CN=C2NC3=C1C=CC(Cl)=C3
Formula: C15H14ClN3O
Pathway: Metabolism
Target: Lipoxygenase
Receptor: N/A
Bioactivity: BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
Molecular Weight: 287, 747
