Product Overview
Bimiralisib | T2265 | TargetMol Chemicals
CAS: 1225037-39-7
Smiles: Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
Formula: C17H20F3N7O2
Pathway: MAPK|||Others|||PI3K/Akt/mTOR signaling
Target: Others|||PI3K|||S6 Kinase|||mTOR
Receptor: N/A
Bioactivity: PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.
Molecular Weight: 411, 389
