Product Overview
BMS-814580 | T26860 | TargetMol Chemicals
CAS: 1197420-11-3
Smiles: COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Formula: C24H19ClF2N2O4S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki of 4.9 and 11.5 nM, respectively). MCHR1 antagonist demonstrates reduction in feeding and body weight in rats and mice.
Molecular Weight: 504, 93
